∙ Patients:

• ≥ 18 years of age at the time of study entry.

• Must be able to speak, read, and understand English.

• Patients with inoperable NSCLC confirmed by histologic or cytologic documentation and by clinical assessment.

• Participants diagnosed with NSCLC, and:

‣ have advanced/metastatic disease who are currently receiving immunotherapy monotherapy, or

⁃ have locally advanced disease who are currently receiving immunotherapy monotherapy after completing thoracic radiation therapy, or

⁃ who underwent resection and are currently receiving immunotherapy monotherapy after completing all other perioperative treatment

• Immunotherapy planned to continue for at least three months after the time of study enrollment (to ensure participant remains on IO long enough to obtain study assessments)

• Have completed at least two cycles of immunotherapy.

• Self-reported cancer-related fatigued that impacts daily function.

∙ Caregivers:

• 18 years of age at the time of study entry.

• A family member or friend helping a patient with NSCLC would be eligible for this study in any of the following ways as outlined by the National Cancer Institute:

• Helping with day-to-day activities such as doctor visits or preparing food

• Giving medicines or helping with physical therapy or other clinical tasks

• Helping with tasks of daily living such as using the bathroom or bathing

• Coordinating care and services from a distance by phone or email

• Giving emotional and spiritual support